2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Methylenetetrahydrofolate dehydrogenase (MTHFD) is a key enzyme in the folate-dependent one carbon metabolism, which is important for the biosynthesis of several amino acids like glycine, alanine and serine, as well as nucleotide bases, formylated methionine and some pro-vitamins. In some bacteria like E. coli, MTHFD (called FolD in this species) is a dual function enzyme that catalyzes the conversion of 5,10-methylenetetrahydrofolate and NADP+ to 5,10-methenyltetrahydrofolate and NADPH (dehydrogenase function), and further converts the first product to 10-formyltetrahdrofolate (cyclohydrolase function). Some microorganisms have a separate enzyme for catalyzing the second cyclohydrolase function (FchA), and some species have an alternative pathway for 10-formyltetrahdrofolate production using formyltetrahydrofolate synthetase (Fhs). In eukaryotes, MTHFD is an important anticancer therapy target.

Methylenetetrahydrofolate Dehydrogenase (MTHFD) Related Products (10):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-130251
    DS18561882
    		99.87%
    DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile.
    DS18561882
  • HY-101943
    LY 345899
    		≥98.0%
    LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1.
    LY 345899
  • HY-131943
    DS44960156
    		99.36%
    DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively.
    DS44960156
  • HY-155950
    TH9619
    		Inhibitor 99.33%
    TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity.
    TH9619
  • HY-149828
    MTHFD2-IN-4
    		Inhibitor
    MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer.
    MTHFD2-IN-4
  • HY-155219
    TH9028
    		Inhibitor
    TH9028 is an inhibitor of MTHFD2 (IC50 = 11 nM) with IC50 values against hMTHFD2, MTHFD2L, and MTHFD1 being 7.97 nM, 27 nM, and 0.5 nM, respectively. TH9028 also exhibits anti-cancer cell proliferation activity.
    TH9028
  • HY-149825
    MTHFD2-IN-1
    		Inhibitor
    MTHFD2-IN-1 (compound 12) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
    MTHFD2-IN-1
  • HY-149828A
    MTHFD2-IN-4 sodium
    		Inhibitor
    MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer.
    MTHFD2-IN-4 sodium
  • HY-149826
    MTHFD2-IN-2
    		Inhibitor
    MTHFD2-IN-2 (compound 13) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
    MTHFD2-IN-2
  • HY-149827
    MTHFD2-IN-3
    		Inhibitor
    MTHFD2-IN-3 (compound 10) is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor.
    MTHFD2-IN-3